Labarai

Me ya sa fiye da 300 lokuta na m hepatitis na ba a sani ba etiology a cikin fiye da 20 kasashe da yankuna a duniya?Sabon bincike ya nuna cewa yana iya kasancewa yana da alaƙa da super antigen da sabon coronavirus ya haifar.An buga binciken da ke sama a cikin mujallar ilimi mai iko ta duniya "Lancet Gastroenterology & Hepatology".

Binciken da aka ambata ya nuna cewa yaran da suka kamu da sabon coronavirus na iya haifar da samuwar tafkunan ƙwayoyin cuta a cikin jiki.Musamman, kasancewar sabon coronavirus a cikin sashin gastrointestinal na yara na iya haifar da sake sakin sunadaran ƙwayoyin cuta a cikin ƙwayoyin epithelial na hanji, wanda ke haifar da kunna rigakafi.Wannan maimaita kunnawar rigakafi na iya yin sulhu ta hanyar babban motsin antigen a cikin furotin mai karu na sabon coronavirus, wanda yayi kama da staphylococcal enterotoxin B kuma yana haifar da faɗuwa da takamaiman kunna tantanin halitta T.Wannan super antigen-mediated kunnawa na rigakafi da ƙwayoyin cuta yana da hannu a cikin multisystem kumburi ciwo a cikin yara (MIS-C).

Abin da ake kira super antigen (SAg) wani nau'in abu ne wanda zai iya kunna yawan adadin ƙwayoyin T cell kuma ya haifar da amsawar rigakafi mai karfi tare da ƙananan ƙwayar cuta (≤10-9 M).Multisystem kumburi ciwo a cikin yara ya fara samun tartsatsi a hankali tun daga watan Afrilu 2020. A lokacin, duniya ta riga ta shiga sabuwar cutar ta kambi, kuma ƙasashe da yawa sun ba da rahoton "bakon cutar yara", wanda ke da alaƙa da sabon kambi. ƙwayar cuta da ake kamuwa.Yawancin marasa lafiya suna fuskantar alamun kamar su zazzabi, kurji, amai, kumburin wuyansa na lymph nodes, chapped lebe, da gudawa, kwatankwacin na cutar Kawasaki, wanda aka fi sani da cutar Kawasaki.Multisystem kumburi ciwo a cikin yara yawanci faruwa makonni 2-6 bayan sabon kambi kamuwa da cuta, da kuma shekaru na farko yara aka mayar da hankali a tsakanin 3-10 shekaru.Ciwon kumburin tsarin Multisystem a cikin yara ya sha bamban da cutar Kawasaki, kuma cutar ta fi tsanani a cikin yaran da ke da alamun cutar COVID-19.

Masu binciken sun bincikar cewa cutar hanta ta kwanan nan da ba a san dalilinta ba a cikin yara na iya kamuwa da sabon coronavirus da farko, kuma yaran sun kamu da adenovirus bayan tafkin kwayar cutar ya bayyana a cikin hanji.

Masu binciken sun ba da rahoton irin wannan yanayin a cikin gwaje-gwajen linzamin kwamfuta: kamuwa da cuta na Adenovirus yana haifar da staphylococcal enterotoxin B-matsakaicin girgiza mai guba, wanda ke haifar da gazawar hanta da mutuwa a cikin mice.Dangane da halin da ake ciki yanzu, ana ba da shawarar ci gaba da sa ido kan COVID-19 a cikin ɗakin yara masu fama da ciwon hanta.Idan an sami shaidar SARS-CoV-2 mai shiga tsakani na rigakafi ta superantigen, yakamata a yi la'akari da maganin immunomodulatory a cikin yara masu tsananin hanta.